Atomic and molecular processes of biomedical interest
2018-2020
Research Programme
Main objectives:
Analysis of the radiobiological effects of low energy electrons and molecular radicals
Characterising potential molecular radiosensitizers
Experiments:
Radical generation by irradiating condensed biomolecular systems
Positive, negative and neutral radical interactions with biologically relevant molecules: DNA, RNA bases and molecular analogues
. Fragmentation induced to molecular radiosensitizers by proton impact (ion accelerator facility-CMAM)
Electron, proton and heavy ion beam Induced molecular damage to living cells
Calculations and models:
Electron and positron scattering cross section from prototype molecules
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Electron transport experiment and modelling: cross-sectional data validation
Modelling electron, positron, proton and heavy ion tracks in soft matter
Members of the research group:
PhD researchers and technical support:
Carlos Guerra (PhD)
Filipe Costa (PhD)
Lidia Álvarez (Technical support)
Close collaborators:
Léon Sanche (University of Sherbrooke)
Alexander Dorn (Max-Plank-Institute Nuclear Physics, Heidelberg)
Stephan Denifl (University of Innsbruck)
Michael Brunger (Flinders University)
Ronal White (James Cook University)
Marcio Bettega (Univesidade Federal do Paraná)
Paulo Limão-Vieira (Universidade Nova de Lisboa)
Simulated photon and electron tracks in liquid water
Hospitals involved in the research project:
Hospital Universitario Ramón y Cajal (Servicio de Radiofísica, Instituto Ramón y Cajal de Investigación Sanitaria)
Hospital Universitario Puerta de Hierro (Instituto de Investigación Sanitaria Puerta de Hierro)
Hospital Universitario La Paz (Servicio de Oncología Radioterápica)
Research Projects:
Ministerio de Ciencia, Innovación y Universidades: FIS2016-80440 (2016-2019)
CSIC: LINKA20085 /2019-2020)
CAPES-Brazil (2019-2022)
Australian Research Council: DP190100696 (2019-2020)
MSCA-ITN-ARGENT-608163 (2014-2018)